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RNA interference: a multifaceted innate antiviral defense

By Ajit Kumar


The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defenses, as well as the full physiological implication of host-pathogen engagement, constitute exciting areas of investigation in the biology of non-coding RNAs

Topics: Commentary
Publisher: BioMed Central
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Provided by: PubMed Central
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    1. (2005). A virus-encoded inhibitor that blocks RNA interference in mammalian cells.
    2. (2007). Agami R: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell
    3. (2005). Akusjarvi G: Suppression of RNA interference by adenovirus virus associated RNA.
    4. (1998). CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elgans.
    5. (2005). Clerzius G: Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity? Retrovirology
    6. (2007). CM: Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci USA
    7. (2005). D: SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature
    8. (2000). DP: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21–23 nucleotide intervals. Cell
    9. (2007). DR: Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nature
    10. (2006). Filipowicz W: Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell
    11. (2000). GJ: An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature
    12. (2001). GJ: Role for a bidentate ribonuclease in the initiation step of RNA interference.
    13. (2007). Hypersusceptibility of vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and miR93 expression. Immunity
    14. (2005). Identification and characterization of human cytomegalovirus-encoded microRNAs.
    15. (2007). Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature
    16. (2000). JC: Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway. P r o c N a t l A c a d S c i U S A
    17. (2005). Jeang K-T: Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. Immunity
    18. (2005). Jeang KT: Changes in microRNA expression profiles in HIV-1-transfected human cells. Retrovirology
    19. (2006). Jeang KT: HIV-1 tar RNA subverts RNA interference in transfected cells through sequestration of TAR RNA binding protein,
    20. (2007). Jeang KT: Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions? Retrovirology
    21. (2007). Kashanchi F: HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol
    22. (2002). LH: A viral suppressor of RNA silencing differentially regulates the accumulation of short interfering RNAs and micro-RNAs in tobacco.
    23. (2007). Majunath N: miRNA profiling of naïve, effector and memory CD8 T cells. PLoS ONE
    24. (2007). Mandelboim O: Host immune system gene targeting by a viral miRNA. Science
    25. (2007). Mechanism of microRNA-mediated gene regulation in animal cells. Trends in Genetic
    26. (2007). Nishikura K: Redirection of silencing targets by adenosine-toinosine editing of miRNAs. Science
    27. (2007). Noncoding RNAs: couplers of analog and digital Information in nervous system function? Trends in Neurosciences
    28. (2006). NW: Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Nature
    29. (2007). PA: Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev
    30. (2005). Sarnow P: Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science
    31. (2007). Sharp PA: microRNAs: A safeguard against turmoil? Cell
    32. (2007). Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science
    33. (2007). Switching from repression to activation: microRNAs can up-regulate translation. Science
    34. (2006). T: MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleus and cytoplasm of rat myogenic cells. Proc Natl Acad Sci USA
    35. (2007). The silent defense: micro-RNA directed defense against HIV-1 replication. Retrovirology
    36. (2007). Transcriptional activation by small RNA duplexes.
    37. (2001). Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature
    38. (2005). Tuschl T: Identification of microRNAs of the herpesvirus family. Nat Methods
    39. (2005). Voinnet O: A cellular microRNA mediates antiviral defense in human cells. Science
    40. (2007). Zhang H: Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nature Medicine

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