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In Vitro Antimycobacterial Activities of Capuramycin Analogues▿

By Venkata M. Reddy, Leo Einck and Carol A. Nacy

Abstract

Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 μg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs

Topics: Susceptibility
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2224724
Provided by: PubMed Central
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