Skip to main content
Article thumbnail
Location of Repository

Immunohistochemical localization of prostate-specific antigen in benign and malignant breast tissues.

By D. J. Howarth, I. B. Aronson and E. P. Diamandis

Abstract

Prostate-specific antigen (PSA), a glycoprotein initially thought to be produced only by the epithelial cells of the prostate, has recently been found in 30% of female breast tumours using immunofluorometry. Our aim was to localize PSA immunohistochemically in a selected group of 27 paraffin-embedded breast tissues. A scoring system was developed for the histological assessment of PSA positivity within the breast tissue. One pathologist (DH) scored, classified and graded all tumours. Site-specific PSA staining was noted in the histology slides. Intense staining was identified in apocrine metaplasia and within the lining ductal epithelium of cystically dilated ducts. The epithelium in lesions of sclerosing adenosis was also frequently positive for PSA staining. Hyperplastic ductal epithelium (especially of mild degree) occasionally stained positive, as did normal breast ducts. Better differentiated tumours showed PSA staining [e.g. mucinous carcinoma (colloid)]. If an infiltrating duct carcinoma showed staining for PSA, adjacent intraductal carcinoma was also noted to stain positively, if present

Topics: Research Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2223538
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (1997). e CancerResearch Campaign 1997Immunohistochemical localization ofprostate-specific antigen in benign andmalignantbreast tissues 1651 Van Krieken JH
    2. (1994). Ectopic production ofprostate specific antigen by a breast tumor metastatic to the ovary.
    3. (1995). New biological functions ofprostate specific antigen?
    4. (1993). Prostate-specific antigen: biochemistry, analytical methods, and clinical application.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.