Location of Repository

Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid

By Magdalena M. Stevanović, Branka Jordović and Dragan P. Uskoković


This paper is covering new, simplistic method of obtaining the system for controlled delivery of the ascorbic acid. Copolymer poly (D,L-lactide-co-glycolide) (DLPLG) nanoparticles are produced using physical method with solvent/nonsolvent systems where obtained solutions were centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenization of water and organic phases. Particles of the DLPLG with the different content of ascorbic acid have different morphological characteristics, that is, variable degree of uniformity, agglomeration, sizes, and spherical shaping. Mean sizes of nanoparticles, which contain DLPLG/ascorbic acid in the ratio 85/150%, were between 130 to 200 nm depending on which stereological parameters are considered (maximal diameters Dmax, feret X, or feret Y). By introducing up to 15% of ascorbic acid, the spherical shape, size, and uniformity of DLPLG particles are preserved. The samples were characterized by infrared spectroscopy, scanning electron microscopy, stereological analysis, and ultraviolet spectroscopy

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:2219224
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles



    1. (2005). Adipose tissue engineering using mesenchymal stem cells attached to injectable
    2. (2002). Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study,”
    3. (2003). Biodegradable nanoparticles for drug and gene delivery to cells and tissue,”
    4. c, “Stereological analysis of the poly-(DL-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing,”
    5. (2001). Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods,”
    6. (2000). Further application of a modified spontaneous emulsification solvent diffusion method to various types of PLGA and PLA polymers for preparation of nanoparticles,”
    7. (2004). I .B a l a ,S .H a r i h a r a n ,a n dM .N .V .R a v iK u m a r ,“ P L G A nanoparticles in drug delivery: the state of the art,” Critical Reviews in Therapeutic Drug Carrier Systems,v o l .2 1 ,n o .5 ,p p .
    8. (2005). Identification of recently handled materials by analysis of latent human fingerprints using infrared spectromicroscopy,”
    9. (1997). In vitro and in vivo respirable fractions of isopropanol treated PLGA microspheres using a dry powder inhaler,”
    10. (1999). Kiremitc ¸i-G¨ um¨ us ¸derelioˇ glu
    11. (2005). Miliˇ cevi´ c, and D. Uskokovi´ c, “Synthesis and characterization of biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite,”
    12. (2006). Nanomedicine: techniques, potentials, and ethical implications,”
    13. (2005). Nanoparticle technology for the production of functional materials,”
    14. (2004). Nanoparticles of biodegradable polymers for clinical administration of paclitaxel,”
    15. (1997). Pharmacological modulation of the tissue response to implanted polylactic-co-glycolic acid microspheres,”
    16. (1997). Physicochemical parameters governing protein microencapsulation into biodegradable polyesters by coacervation,”
    17. (2004). Preparation and characterization of cationic
    18. (2003). Preparation of poly(DL-lactide-co-glycolide) microspheres encapsulating alltrans retinoic acid,”
    19. (1999). Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method,”
    20. (1988). Quantitative Image Analysis of Microstructures,
    21. (1970). Quantitative Stereology,
    22. (1984). Structure of ascorbic acid and its biological function. Determination of the conformation of ascorbic acid and isoascorbic acid by infrared and ultraviolet investigations,”

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.