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CD40 and CD80/86 Act Synergistically to Regulate Inflammation and Mortality in Polymicrobial Sepsis

By Anna Nolan, Michael Weiden, Ann Kelly, Yoshihiko Hoshino, Satomi Hoshino, Nehal Mehta and Jeffrey A. Gold

Abstract

Rationale: Costimulatory molecules, including the CD40–CD154 and CD80/86–CD28 dyads, play a prominent role in regulating inflammation in the adaptive immune response. Studies from our group and others suggest a potentially important role for these costimulatory cascades in innate immunity as well

Topics: D. Critical Care
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2218847
Provided by: PubMed Central
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