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IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites

By Alexandre Morrot, Julius C.R. Hafalla, Ian A. Cockburn, Luzia H. Carvalho and Fidel Zavala


IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is lost. These results demonstrate that IL-4/IL-4R interactions on CD8+ T cells play a critical role in modulating the development and tissue distribution of memory cells induced by parasite immunization. They also indicate that memory cells residing in nonlymphoid tissues are critical for protective immunity against malaria parasites

Topics: Article
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:2212849
Provided by: PubMed Central
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    1. (1997). (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4.
    2. (2004). Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin.
    3. (1997). An interleukin 4 (IL-4)-independent pathway for CD4 T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
    4. (1998). Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure.
    5. (2003). CD8 T cell responses to infectious pathogens.
    6. cell type 1-associated and cytotoxic T lymphocytemediated tumor immunity is impaired in interleukin 4-deficient mice.
    7. (2002). Cutting edge: CCR7 and CCR7- memory T cells do not differ in immediate effector cell function.
    8. (2003). Cytokine control of memory T-cell development and survival.
    9. (1993). Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells.
    10. (2001). Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.
    11. (2002). IL-4-secreting CD4 T cells are crucial to the development of CD8 T-cell responses against malaria liver stages.
    12. (2004). Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8 T cells.
    13. (2001). Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.
    14. (2003). Lineage relationship and protective immunity of memory CD8 T cell subsets.
    15. (2004). Memory CD8 T-cell differentiation during viral infection.
    16. (2002). Molecular and functional profiling of memory CD8 T cell differentiation.
    17. (2003). Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8( ) T-cell responses.
    18. (2000). Potent induction of long-term CD8 T cell memory by short-term IL-4 exposure during T cell receptor stimulation.
    19. (2001). Preferential localization of effector memory cells in nonlymphoid tissue.
    20. (2002). Progressive differentiation and selection of the fittest in the immune response.
    21. (2002). Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus.
    22. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.
    23. Swift development of protective effector functions in naive CD8( ) T cells against malaria liver stages.
    24. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
    25. (2003). Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

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