Location of Repository

ALBUMIN AND GLOBULIN CIRCULATION IN EXPERIMENTAL ASCITES : RELATIVE RATES OF INTERCHANGE BETWEEN PLASMA AND ASCITIC FLUID STUDIED WITH C14-LABELED PROTEINS

By F. W. McKee, C. L. Yuile, B. G. Lamson and G. H. Whipple

Abstract

Plasma containing carbon14-labeled albumin and globulin, obtained by feeding ε-C14 D,L.-lysine to a donor dog, has been injected intravenously and intraperitoneally into recipient dogs with experimental ascites. The circulation and interchange of total plasma protein between circulating blood and ascitic fluid have been confirmed and the participation of both albumin and globulin in this interchange has been demonstrated. Labeled albumin tends to reach equilibrium in plasma and ascitic fluid in a shorter period of time (1 to 2 days) than does globulin (2 or more days), after administration of labeled plasma by either route. Evidence is presented that the rate of transfer of albumin across the peritoneal membrane is at least three times faster than that of globulin in terms of weight

Topics: Article
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:2212054
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.