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The Role of Macrophages in Demyelinating Peripheral Nervous System of Mice Heterozygously Deficient in P0

By Stefano Carenini, Mathias Mäurer, Alexander Werner, Heinrich Blazyca, Klaus V. Toyka, Christoph D. Schmid, Gennadij Raivich and Rudolf Martini

Abstract

Mice heterozygously deficient in the p0 gene (P0+/−) are animal models for some forms of inherited neuropathies. They display a progressive demyelinating phenotype in motor nerves, accompanied by mild infiltration of lymphocytes and increase in macrophages. We have shown previously that the T lymphocytes are instrumental in the demyelination process. This study addresses the functional role of the macrophage in this monogenic myelin disorder

Topics: Original Article
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:2199607
Provided by: PubMed Central

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