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Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C

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Abstract

Natural killer (NK) cells express killer inhibitory receptors that mediate negative regulation of NK cell cytotoxicity upon binding to MHC class I molecules on target cells. Unrelated inhibitory receptors on B cells have recently been shown to function through recruitment of phosphotyrosine phosphatase 1C (PTP-1C). Here, we show that a human killer inhibitory receptor specific for HLA-C also recruits PTP-1C after phosphorylation induced either by the pharmacological agent phenylarsine oxide or by conjugation with target cells. This recruitment is mediated by the binding of specific cytoplasmic phosphotyrosine-containing sequences to PTP-1C. These results implicate PTP-1C as a cytosolic component of the negative signaling pathway through NK cell inhibitory receptors

Topics: Articles
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:2192677
Provided by: PubMed Central

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Citations

  1. (1994). A 13-amino-acid motif in the cytoplasmic domain of Fc gamma PMB modulates 99 Campbell et al. B-cell receptor signalling.
  2. (1989). A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.
  3. (1991). A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
  4. (1995). A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science (Wash.
  5. (1990). A simple method for the radioactive iodination of CD4 molecules.
  6. (1993). CD22 associates with the human surface IgM-B-cell antigen receptor complex.
  7. Characterization of hematopoietic intracellular protein tyrosine phosphatase: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.
  8. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage.
  9. (1988). Cloning and expression ofa cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  10. (1995). Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science (Wash.
  11. (1992). Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science (Wash.
  12. (1995). Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.
  13. (1993). HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.
  14. (1994). Induction of hyperphosphorylation and activation of the p561ck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor.
  15. (1995). Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I.
  16. (1989). Isolation and expression of a cDNA clone encoding HLA-Cw6: unique characteristics of HLA-C encoded gene products.
  17. (1992). Isolation of a src homology 2-containing tyrosine phosphatase.
  18. (1995). Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.
  19. (1995). Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.
  20. (1995). Molecular cloning of NKB1, a natural killer cell receptor for HLA-B allotypes.
  21. (1994). NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine
  22. (1994). NKBI: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.
  23. (1995). OflTAMs and ITAMs: turning on and offthe B cell antigen receptor.J.
  24. (1993). p58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.J.
  25. (1989). Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.J.
  26. (1992). Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hemopoietic cells, and localization to human chromosome 12p12-p13.
  27. (1995). R.ecruitment and activation of PTPIC in negative regulation of antigen receptor signaling by Fc~R.IIB1. Science (Wash.
  28. (1993). Recognition structures on natural killer cells.
  29. (1995). Right-side-up and up-side-down NK-cell receptors.
  30. (1995). Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role ofT cell actin cytoskeleton.J.
  31. (1994). Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes.J.
  32. (1990). Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

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