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Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity

By Byeong-ryool Jeong, Yan Lin, Anna Joe, Ming Guo, Christin Korneli, Huirong Yang, Ping Wang, Min Yu, Ronald Cerny, Dorothee Staiger, James R. Alfano and Yanhui Xu


Background: HopU1 ADP-ribosylates GRP7, suppressing plant immunity. Results: The HopU1 structure has two novel loops required for GRP7 recognition, and HopU1 ribosylates GRP7 at an arginine in position 49 disrupting its function. Conclusion: HopU1 targets a conserved arginine in GRP7, disabling its ability to bind immunity-related RNA. Significance: The mechanistic details of how HopU1 recognizes its substrate reveal how HopU1 contributes to pathogenesis

Topics: Analytical Chemistry, Chemistry, Medicinal-Pharmaceutical Chemistry, Other Chemistry, Physical Sciences and Mathematics
Publisher: DigitalCommons@University of Nebraska - Lincoln
Year: 2011
DOI identifier: 10.1074/jbc.m111.290122
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