10.1158/0008-5472.CAN-08-2510

Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells

Abstract

Studies on human fibroblasts have led to viewing senescence as a barrier against tumorigenesis. Using keratinocytes, we show here that partially transformed and tumorigenic cells systematically and spontaneously emerge from senescent cultures. We show that these emerging cells are generated from senescent cells, which are still competent for replication, by an unusual budding-mitosis mechanism. We further present data implicating reactive oxygen species that accumulate during senescence as a potential mutagenic motor of this post-senescence emergence. We conclude that senescence and its associated oxidative stress could be a tumor-promoting state for epithelial cells, potentially explaining why the incidence of carcinogenesis dramatically increases with advanced age. ©2009 American Association for Cancer Research.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Similar works

Full text

DI-fusionProvided a free PDF (195.62 KB)

2013/180880oai:dipot.ulb.ac.be:2013/180880
Last time updated on February 23, 2017

This paper was published in DI-fusion.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.