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Solid Tumour Models for the Assessment of Different Treatment Modalities: VII: Single vs Fractionated Doses of 5-Fluorouracil on Two Solid Tumours and Their Hosts

By W. B. Looney, M. S. MacLeod and H. A. Hopkins


The effects of one large single dose of 5-fluorouracil (FU) have been compared to the same amount given in divided doses daily over a 3- or 5-day period. Comparison of the effects of single vs fractionated dosage was made on 2 types of experimental solid tumour with different growth, cell kinetic, histological and metastasizing properties. The tumour response was essentially the same for both the single and fractionated dose schedules

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