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Differences in Metabolism of Vinylidene Chloride Between Mice and Rats

By B. K. Jones and D. E. Hathway

Abstract

The present finding that mice metabolize a greater proportion of an oral dose (50 mg/kg) of vinylidence chloride. (1,1 - dichloroethylene, DCE) than rats implies (a) that the efficiency of DCE metabolism follows the known activity of cytochrome P-450 in the organs of these animals, and (b) that, in accordance with the LD50 values, the real exposure (expressed as the amount of DCE metabolized) is relatively higher for orally dosed mice than rats, and (c) that DCE carcinogenicity would appear to be more likely in mice than rats

Topics: Articles
OAI identifier: oai:pubmedcentral.nih.gov:2009538
Provided by: PubMed Central

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