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Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

By M. Wheeler, A. Chardon, A. Goubet, K. Morihiro, S.Y. Tsan, S.L. Edwards, T. Kodama, S. Obika and R.N. Veedu

Abstract

Enzymatic recognition of SeLNA nucleotides was investigated. KOD XL DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of SeLNA-modified DNA templates was also efficiently achieved by Phusion and KOD XL DNA polymerases

Publisher: Royal Society of Chemistry
Year: 2012
OAI identifier: oai:researchrepository.murdoch.edu.au:27406
Provided by: Research Repository
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