Location of Repository

An ultrastructural study of skeletal muscle in polymyositis

By F.L. Mastaglia and J.N. Walton

Abstract

Biopsy material from the quadriceps femoris muscle in a case of subacute polymyositis associated with polyarthropathy and transient cardiac involvement has been examined with the electron microscope. Observations have been made on the ultrastructural changes in necrotic muscle fibres as well as on the origin and differentiation of myoblasts participating in the regenerative processes in damaged fibres. An unexpected finding was the presence of granular cytoplasmic inclusions and nuclear abnormalities in some regenerating muscle fibres. Although the particles in the inclusions are similar to those seen in cells infected with Coxsackie virus, the possibility that the inclusions are unusually large aggregates of glycogen granules cannot be excluded. Thickening of endothelial cells and thickening and reduplication of the basement membrane of capillaries and venules was also found but is not considered to be of primary importance in the pathogenesis of the muscle fibre damage

Publisher: Elsevier BV
Year: 1971
OAI identifier: oai:researchrepository.murdoch.edu.au:26131
Provided by: Research Repository
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://researchrepository.murd... (external link)
  • http://researchrepository.murd... (external link)
  • http://researchrepository.murd... (external link)
  • http://researchrepository.murd... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.