Quantitative fiber tracking in corpus callosum and internal capsule reveals microstructural abnormalities in preterm infants at term equivalent age

Abstract

Background and Purpose Signal abnormalities in posterior limb of the internal capsule (PLIC) and thinning of corpus callosum (CC) are often seen in preterm infants and associated with poor outcome. Diffusion Tensor Imaging (DTI) is able to detect subtle abnormalities. We used fiber tracking to select bundles of interest (CC and PLIC) to acquire additional information on the white matter injury (WMI). Methods One-hundred-twenty preterm infants bor