Article thumbnail
Location of Repository

Orosomucoid, a new biomarker in the association between obesity and periodontitis.

By Hélène Rangé, Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, Jean-Marc Lacorte, Sébastien Czernichow, Olivier Meilhac, Philippe Bouchard and Catherine Chaussain


International audienceEpidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p<0.04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels

Topics: MESH: Adult, MESH: Biomarkers, MESH: Male, MESH: Middle Aged, MESH: Obesity, Morbid, MESH: Orosomucoid, MESH: Periodontitis, MESH: Risk Factors, MESH: C-Reactive Protein, MESH: Cross-Sectional Studies, MESH: Female, MESH: Humans, MESH: Inflammation Mediators, [SDV]Life Sciences [q-bio]
Publisher: Public Library of Science
Year: 2013
DOI identifier: 10.1371/journal.pone.0057645
OAI identifier: oai:HAL:hal-01446905v1
Provided by: HAL-Inserm
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://hal.archives-ouvertes.... (external link)
  • https://hal.archives-ouvertes.... (external link)
  • https://hal.archives-ouvertes.... (external link)
  • https://hal.archives-ouvertes.... (external link)
  • https://hal.archives-ouvertes.... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.