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Resuscitation-promoting factors possess a lysozyme-like domain

By M. Cohen Gonsaud, Nicholas H. Keep, A.P. Davies, J.M. Ward, B. Henderson and G. Labesse

Abstract

The novel bacterial cytokine family – resuscitation-promoting factors (Rpfs) – share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs

Topics: bcs
Publisher: Elsevier
Year: 2004
OAI identifier: oai:eprints.bbk.ac.uk.oai2:370

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