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Clinical outcomes of oral squamous cell carcinomas treated by surgery over 9 years : a comparison of results to those in a 2003 international collaborative study

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Abstract

2004 年 1 月から 2012 年 12 月までの 9 年間に札幌医科大学附属病院歯科口腔外科を受診した口腔悪性腫瘍患者は 332 例で,この中の口腔扁平上皮癌(口腔癌)183 例に外科治療を行った。治療経過と転帰について海外 7 か国,7 施設による口腔癌 2003 例を集積した国際共同研究のデータと比較検討を行うことでわれわれの治療方針の検証を行った。国際共同研究における全症例の 5 年病因特異的および 5 年全生存率,stage I, II の 5 年全生存率,stage III,IV の 5 年全生存率は 81%,70%,77%,63% であった。札幌医科大学で治療を行った 183 例の同生存率は 85%,77%,85%,63% で,国際標準に劣らない治療結果を示した。この臨床データを基に治療および予後因子の検索を行うのが課題である。A total of 332 malignant neoplasms of the oral cavity were recorded at Department of Oral Surgery, Sapporo Medical University (OSSMU) between January 2004 and December 2012. Of these, the clinical outcomes of 183 oral squamous cell carcinomas (OSCC) treated by surgery were analyzed. These results were carefully compared with those seen in a 2003 international collaborative study, which are widely considered the global standard concerning OSCC survival rates. The five-year disease-specific survival rate for the 183 patients was 85% and the overall survival rate was 77%. For stage I and II patients, the overall survival rate was 85% and for stage III and IV patients, the rate of overall survival was 63%. These rates compared favorably to those from the 2003 study (81%, 70%, 77% and 63%). Based on these results, future OSSMU studies should focus on the potential favorable and unfavorable factors of OSCC

Topics: oral squamous cell carcinoma, surgical treatment, global standard survival
Publisher: 札幌医科大学医学部
Year: 2015
OAI identifier: oai:ir.cc.sapmed.ac.jp:123456789/6606
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