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ジフテリア・アレルギーに関する実験的研究 第1篇 ジフテリア毒素, トキソイド及び生菌感作家兎における毒素及びトキソイドの皮膚アレルギー反応について



Purified toxin and toxoid of various concentrations were reinjected into the skin of rabbits immunized with diphtheteria anatoxin, purified toxin or toxoid, and the skin reactions were investigated. The allergic skin reaction caused with the toxin was almost similar to that caused with the toxoid, and the reaction was observed to appear earlier and more pronounced than those in control animals. Characteristic hemorrhagic necrosis was observed in the skin of the control animals, while in the immunized animals exudative and degenerative lesions were found in the walls of blood vessels and connective tissues, which could be considered as characteristic of allergic reaction

Publisher: 札幌医科大学医学部
Year: 1954
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