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Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid



Altered functioning of the glutamate system during critical periods of development is believed to play a role in various neurodevelopmental disorders, such as schizophrenia. Prepulse inhibition (PPI) of the acoustic startle response is deficient in people with schizophrenia. This study investigated the theory that neonatal treatment with domoic acid (DOM), a glutamate agonist, leads to deficient PPI. Results indicate that neonatal treatment with DOM leads to lowered PPI in adult males and an increased startle response in adult females.Accession Number: 17973071. Date Created: 20080605. Date Completed: 20080819. Update Code: 20081217. Publication Type: Journal Article; Research Support, Non-U.S. Gov't. Journal ID: 9200312. Publication Model: Print-Electronic. Cited Medium: Internet. NLM ISO Abbr: Amino AcidsSource type: Electronic(1

Topics: Glutamic Acid*/metabolism--Kainic Acid/*analogs & derivatives--Neuromuscular Depolarizing Agents/*toxicity--Reflex, Acoustic/*drug effects--Schizophrenia/*chemically induced--Startle Reaction/*drug effects--Animals--Animals, Newborn--Disease Models, Animal--Female--Humans--Kainic Acid/toxicity--Male--Rats--Schizophrenia/metabolism--Sex Factors--Time Factors
Publisher: 'Springer Science and Business Media LLC'
DOI identifier: 10.1007/s00726-007-0603-3
OAI identifier:
Provided by: IslandScholar
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