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Charge fluctuations and boundary conditions of biological ion channels : effect on the ionic transition rate

By R. Tindjong, D. G. Luchinsky, P. V. E. McClintock and R. S. Eisenberg


A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration

Year: 2009
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Provided by: Lancaster E-Prints

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