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Entrepreneurial Experiments in Science Policy: Analizing the Human Genome Project

By Kenneth G. Huang and Fiona E. Murray

Abstract

We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments and initiate them. We argue that reframing science policy around the notion of conducting entrepreneurial experiments – experiments that increase the diversity of technical, organizational and institutional arrangements in which scientific research is conducted – can provide policy makers with a wider repertoire of effective interventions. To illustrate the power of this approach, we analyze the Human Genome Project (HGP) as a set of successful, entrepreneurial experiments in organizational and institutional innovation. While not designed as such, the HGP was an experiment in funding a science project across a variety of organizational settings, including seven public and one private (Celera) research centers. We assess the major characteristics and differences between these organizational choices, using a mix of qualitative and econometric analyses to examine their impact on scientific progress. The planning and direction of the Human Genome Project show that policy makers can use the levers of entrepreneurial experimentation to transform scientific progress, much as entrepreneurs have transformed economic progress.Entrepreneurial Experiments; Science Policy; Human Genome Project

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Citations

  1. (5). http://www.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v4n5/04share.shtml U.S. Department of Energy,
  2. (1993). A new five-year plan for the U.S. Human Genome Project.
  3. (2001). Annals of Medicine: The Thirty Years’ War.
  4. (1992). Cover Story – This Genetic Map will Lead to a Pot of Gold.
  5. (1999). Distribution-free estimation of some nonlinear panel data models.
  6. (2007). Do formal intellectual property rights hinder the free flow of scientific knowledge? An empirical test of the anti-commons hypothesis.
  7. (2005). Economic experiments: the role of entrepreneurship in economic prosperity. In: Understanding Entrepreneurship: A Research and Policy Report, Ewing Marion Kauffman Foundation.
  8. (1992). Economic experiments.
  9. (1962). Economic welfare and the allocation of resources for invention. In: The Rate and Direction of Inventive Activity.
  10. (2001). Genome Sequencing Consortium,
  11. (2000). Genomics: journey to the center of biology.
  12. (1986). Glittering prizes for research support,
  13. (2009). Grant System Leads Cancer Researchers to Play It Safe.
  14. (1999). Hot Papers In Genomics:
  15. (1999). Human Gene Patents Defended. 27 October.
  16. (2001). Initial sequencing and analysis of the human genome. International Human Genome Sequencing Consortium.
  17. (2000). Innovation policy experiment at the regional level. Workshop on the regional level of implementation of innovation and education and training policies,
  18. (2005). Intellectual property landscape of the human genome.
  19. (2009). Intellectual Property Rights and Innovation: Evidence from the Human Genome. Working paper,
  20. (2009). Knowledge production in innovative firms under uncertain intellectual property conditions. In:
  21. (1991). Large-scale and automated DNA sequence determination.
  22. (1994). Measuring competence? Exploring firm effects in pharmaceutical research.
  23. (2008). Multi-university research teams: shifting impact, geography, and stratification in science.
  24. (2009). Of Mice and Academics: The Role of Openness in Science. MIT Sloan Working Paper.
  25. (2006). Prizes for Technological Innovation. Brookings Institution Working Paper No.
  26. (1996). Program Human Genome News, January-March, 7 (5). http://www.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v7n5/05detail.shtml U.S. Department of Energy,
  27. (2001). Public/private partnerships: stimulating competition in a dynamic market.
  28. (2009). Science innovation: assessing the impact of science funding.
  29. (1945). Science: The endless frontier. United States Government Printing Office,
  30. (1989). Scientists Calling for U.S. to Spend $3 Billion to Identify Human Genes.
  31. (2003). Scientists Complete Human Genome Project.
  32. (1990). Scientists Find First Clues on How Gene Could Cause Nerve Tumors.
  33. (2009). The Environment and Directed Technical Change.
  34. (1989). The Man behind the Double Helix; Gene-buster James Watson Moves on to Biology’s Biggest Challenge – Mapping Heredity.
  35. (1959). The simple economics of basic scientific research.
  36. (2009). TIP’s Competition in 2009. March. http://www.nist.gov/tip/ U.S. Department of Energy,
  37. (1961). Uncertainty, learning, and the economics of parallel research and development efforts.
  38. (2005). View from the bench: patents and material transfers.
  39. (2007). Was there too little entry during the dot com era?

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