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Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation

By I P Alwayn, J Z Appel, C Goepfert, Leo Hans Buehler, D K Cooper and S C Robson


Activation of endothelial cells and platelet sequestration play major roles in rejection of xenografts. The histopathology of both hyperacute and acute vascular or delayed rejection of vascularized discordant xenografts is characterized by interstitial hemorrhage and intravascular thrombosis. Agents that prevent platelet activation and consequent microthrombus formation have proven beneficial in xenograft rejection but do not fully preclude vascular thrombosis. Recently, several new anti-platelet therapies have undergone extensive clinical testing for atherosclerotic thrombotic vascular disorders; other putative therapies are undergoing pre-clinical evaluation. We have investigated the effect of several of these novel agents on platelet aggregation in baboons in order to screen for future potential in xenograft rejection models

Topics: info:eu-repo/classification/ddc/617, Animals, Anticoagulants/pharmacology, Aurintricarboxylic Acid/pharmacology, Blood Coagulation/drug effects, Blood Platelets/drug effects, Epoprostenol/pharmacology, Heparin/pharmacology, Papio, Platelet Aggregation/drug effects, Platelet Aggregation Inhibitors/pharmacology, Polysaccharides/pharmacology, Thromboxane A2/pharmacology, Transplantation, Heterologous/physiology
Publisher: 'Wiley'
Year: 2000
DOI identifier: 10.1034/j.1399-3089.2000.00965.x
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Provided by: Archive ouverte UNIGE
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