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Development and validation of computational models of cellular interaction

By R.H. [] Smallwood, W.M.L. Holcombe and D.C. Walker


In this paper we take the view that computational models of biological systems should satisfy two conditions –\ud they should be able to predict function at a systems biology level, and robust techniques of validation against\ud biological models must be available. A modelling paradigm for developing a predictive computational model of\ud cellular interaction is described, and methods of providing robust validation against biological models are\ud explored, followed by a consideration of software issues

Year: 2004
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