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Development and validation of computational models of cellular interaction

By R.H. [r.smallwood@shef.ac.uk] Smallwood, W.M.L. Holcombe and D.C. Walker

Abstract

In this paper we take the view that computational models of biological systems should satisfy two conditions –\ud they should be able to predict function at a systems biology level, and robust techniques of validation against\ud biological models must be available. A modelling paradigm for developing a predictive computational model of\ud cellular interaction is described, and methods of providing robust validation against biological models are\ud explored, followed by a consideration of software issues

Year: 2004
OAI identifier: oai:eprints.whiterose.ac.uk:420

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