Skip to main content
Article thumbnail
Location of Repository

A case control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis

By P T Wilmshurst, R N Stevenson, H Griffiths and John R Lord


Objective To investigate the relation of hyperlipidaemia to calcific aortic valve stenosis.\ud Design A case-control study designed to detect a clinically relevant difference in the fasting plasma concentrations of total cholesterol between the groups at the 5% level with a power of 90%. Predefined subgroup analyses were based on presence of significant coronary disease and valve morphology (that is, bicuspid or tricuspid).\ud Setting A district general hospital.\ud Subjects 20 patients with severe calcific aortic stenosis and 20 controls.\ud Results Mean (SD) fasting plasma total cholesterol in patients with aortic stenosis was 0.79 (1.50) mmol/l greater than in the controls (p = 0.029). The magnitude of differences between patients with aortic stenosis and controls was similar whether the patients had coronary artery disease (0.78 (1.73) mmol/l) or not (0.80 (1.37) mmol/l). The presence of a stenosed tricuspid aortic valve was associated with a significant increase in plasma cholesterol (1.70 (0.87) mmol/l, p = 0.012). For bicuspid valves the degree of elevation of plasma cholesterol was less and not statistically significant.\ud Conclusions Calcific aortic stenosis is associated with hypercholesterolaemia, especially when the valve is tricuspid. Further studies are necessary to confirm that the relation is causal. This finding may have implications for measures to prevent the most common cause of cardiac valve replacement in the developed world

Topics: RC
Publisher: BMJ Publishing Group
Year: 1997
OAI identifier:

Suggested articles


  1. (1995). Pathology of aortic stenosis in the elderly.Cardiol Elderly
  2. Demographic characteristics of patients undergoing aortic valve replacement for stenosis: relation to valve morphology.Heart 1996;75:174– doi
  3. Characterization of the early lesions of “degenerative” valvular aortic stenosis.Circulation 1994;90: doi
  4. (1992). Reported frequency of coronary arterial narrowing by angiogram in patients with valvular aortic stenosis. doi
  5. (1993). Progression of aortic stenosis. Role of age and concomitant coronary artery disease.
  6. Hydraulic formula for calculation of area of stenotic mitral valve, other cardiac valves and central circulatory shunts. doi
  7. (1993). Clinical factors useful in predicting aortic valve structure in patients >40 years of age with isolated valvular aortic stenosis. doi
  8. (1984). Diabetes and hypercholesterolaemia among patients with calcific aortic stenosis. doi
  9. Case–control analysis of risk factors for presence of aortic stenosis in adults (age 50 years or older). doi
  10. Aortic stenosis in homozygous familial hypercholesterolaemia. doi
  11. Serum cholesterol, lipoproteins, and the risk of coronary heart disease: the Framingham Study. Ann Intern Med doi
  12. (1986). Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT. doi
  13. (1994). Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study. Lancet doi
  14. (1995). Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.