Skip to main content
Article thumbnail
Location of Repository

Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation

By Emma Wightman, Crystal Haskell, Joanne Forster, Rachel Veasey and David Kennedy

Abstract

Objective\ud The aim of the study was to assess the effects of oral ingestion of the ‘green tea’ polyphenol epigallocatechin gallate (EGCG) on cognitive performance, mood and localised cerebral blood flow (CBF) parameters in healthy human adults.\ud \ud Method\ud In this double-blind, placebo-controlled, crossover study, 27 healthy adults received placebo and two doses (135 and 270 mg) of EGCG in counterbalanced order on separate days. Following a 45-min resting absorption period, participants performed a selection of computerised cognitive tasks that activate the frontal cortex for a further 42 min. CBF and haemodynamics, as indexed by concentration changes in oxygenated and deoxygenated haemoglobin, were assessed in the frontal cortex throughout the post-treatment period using Near-infrared spectroscopy (NIRS).\ud \ud Results\ud During the post-dose task performance period, the administration of 135 mg EGCG resulted in reduced CBF in the frontal cortex, as indexed by significantly lower concentrations of both oxygenated and total haemoglobin, in comparison with placebo. Heart rate was significantly reduced from pre dose to post dose across all treatments. No significant differences were observed for the level of deoxygenated haemoglobin or on any of the cognitive performance/mood measures.\ud \ud Conclusions\ud These results demonstrate that a single dose of orally administered EGCG can modulate CBF parameters in healthy humans but that this is not associated with changes in cognitive performance or mood

Topics: B200, C800
Publisher: Wiley-Blackwell
Year: 2012
OAI identifier: oai:nrl.northumbria.ac.uk:5653

Suggested articles

Citations

  1. (1997). (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-
  2. (2004). (-)-Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism. Naunyn-Schmiedeberg's archives of pharmacology 369: doi
  3. (2009). (-)-Epigallocatechin-3-gallate prevents lipopolysaccharideinduced elevation of beta-amyloid generation and memory deficiency. doi
  4. (2006). (–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. doi
  5. (2004). A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMPdependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. doi
  6. (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans. doi
  7. (2006). A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. doi
  8. (2007). Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. doi
  9. (2011). Acute resveratrol supplementation improves flowmediated dilatation in overweight/obese individuals with mildly elevated blood pressure. doi
  10. (2007). Altered frontal brain oxygenation in detoxified alcohol dependent patients with unaffected verbal fluency performance. Psychiatry Research: doi
  11. (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. doi
  12. (2003). Beyond the visible - Imaging the human brain with light. doi
  13. (2009). Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects. doi
  14. (2001). Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study.
  15. (1998). Catechin metabolites after intake of green tea infusions. doi
  16. (2011). Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: A Near Infrared Spectroscopy study. doi
  17. (2002). Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatment. doi
  18. (2007). Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats.
  19. (2002). Cognitive mechanisms of nicotine on visual attention. doi
  20. (2004). Comparison of caffeine-induced changes in cerebral blood flow and middle cerebral artery blood velocity shows that caffeine. doi
  21. (2010). Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. doi
  22. (2007). Daily consumption of green tea catechin delays memory regression in aged mice. doi
  23. (1991). Design and analysis.
  24. (2008). Dimenhydrinate effect on cerebral oxygen status and salivary chromogranin-A during cognitive tasks. doi
  25. (1997). Dose-dependent incorporation of tea catechins,(-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. doi
  26. (2007). Effect of cocoa and tea intake on blood pressure: a metaanalysis. Archives of internal medicine 167: doi
  27. (2003). Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. doi
  28. (2002). Effects of catechins on vascular tone in rat thoracic aorta with endothelium. doi
  29. (2007). Effects of flavonoid-containing beverages and EGCG on endothelial function. doi
  30. (2010). Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. doi
  31. (2007). Epigallocatechin-3-gallate suppresses NF-kappa B activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. doi
  32. (1998). Food Chem 50: 3435-3443. Page 28 of 32 http://mc.manuscriptcentral.com/hup Human Psychopharmacology: Clinical and Experimental 60For Peer Review Suganuma
  33. (2008). Functional near-infrared spectroscopy: A longterm reliable tool for measuring brain activity during verbal fluency. doi
  34. (2007). Functional near-infrared spectroscopy: current status and future prospects. doi
  35. (2009). Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved. Basic research in cardiology 104: doi
  36. (2009). Green and black tea consumption and risk of stroke: a meta-analysis. doi
  37. (2003). Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways. doi
  38. (2008). Green tea epigallocatechin-3-gallate (EGCG) reduces [beta]-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. doi
  39. (2004). Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats. doi
  40. (2005). Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth. doi
  41. (2001). Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. doi
  42. (2004). Green tea reverses endothelial dysfunction in healthy smokers. doi
  43. (2005). Human performance assessment using fNIR. Proceedings of SPIE: Biomonitoring for physiological and cognitive performance during military operations. Citeseer: Sorond doi
  44. (2002). Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species. doi
  45. (2005). Illuminating the BOLD signal: combined fMRI-fNIRS studies. doi
  46. (2008). Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guarana (Paullinia cupana). doi
  47. (1997). Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. doi
  48. (2000). Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells.
  49. (1993). Investigations of the functional anatomy of attention using the Stroop test. doi
  50. (1996). L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice. doi
  51. (1997). Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. doi
  52. (2002). Near-infrared spectroscopy can detect brain activity during a color-word matching Stroop task in an event-related design. Human brain mapping doi
  53. (2009). Neuronal Nitric Oxide Synthase and Human Vascular Regulation. Trends in doi
  54. (2008). Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. doi
  55. (2006). Neuroprotective effects of resveratrol on cerebral ischemiainduced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. doi
  56. (2004). Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects. doi
  57. (2002). Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and (-)-Epigallocatechin-3-gallate by Humans.
  58. (2005). Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. doi
  59. (2004). Prefrontal cortical activation associated with working memory in adults and preschool children: an event-related optical topography study. doi
  60. (2003). Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal.
  61. (2000). Relative contributions from neuronal and endothelial nitric oxide synthases to regional cerebral blood flow changes during forebrain ischemia in rats. doi
  62. (2009). Resting cerebral blood flow, attention, and aging. doi
  63. (2007). Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. doi
  64. (2004). Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. doi
  65. (2007). Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex. doi
  66. (2003). Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. doi
  67. (2008). Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases. doi
  68. (2005). Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. doi
  69. (1999). Sleep deprivation-induced reduction in cortical functional response to serial subtraction. doi
  70. (2006). Study of the mechanisms involved in the vasorelaxation induced by (-)-epigallocatechin-3-gallate in rat aorta. British journal of pharmacology. doi
  71. (2001). Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles. doi
  72. (2002). Tea as a functional food for oral health. doi
  73. (2002). Tea catechin, (-)-epigallocatechin gallate, facilitates cholinergic ganglion transmission in the myenteric plexus of the guinea-pig small intestine. doi
  74. (2007). Tea polyphenols for health promotion. doi
  75. (2008). The acute effect of green tea consumption on endothelial function in healthy individuals. doi
  76. (1991). The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan. doi
  77. (1969). The distribution of polyphenols in the tea plant (Camellia sinensis L.).
  78. (2006). The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice. doi
  79. (1990). The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. doi
  80. (2003). The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. doi
  81. (2002). Vinpocetine increases cerebral blood flow and oxygenation in stroke patients: a near infrared spectroscopy and transcranial Doppler study. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.