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What is the interrelation of protein structure and physical behaviour and how is it influenced by environmental conditions?

By Daniel J. Belton and Aline F. Miller

Abstract

Proteins are essential for life and as such have been deemed useful as therapeutic agents. However, the complexities that make proteins important for biological processes can also make their behaviour complicated. Such behaviour can make production, processing and formulation of protein pharmaceuticals problematic. A therapeutic protein test system has been examined using infrared spectroscopy and differential scanning calorimetry to increase understanding of its behaviour. It has been show that the protein thermally denatures at 47 °C and that this is accompanied by changes to the structure

Topics: TP, QD
OAI identifier: oai:eprints.hud.ac.uk:5020

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Citations

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