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Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine

By G. Huf, E.S.F. Coutinho, C.E. Adams, R.V.S. Borges, M.A.V. Ferreira, F.J.F. Silva, A.J.C.R. Pereira, A.M. Abreu, S.M. Lugao, M.P.C.P. Santos, M. Gewandsznajder, V.R.P. Mercadante, W. Lange and C.L. Dias


OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness. \ud \ud DESIGN: Pragmatic, randomised clinical trial. \ud \ud SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil. \ud \ud SUBJECTS: 301 aggressive or agitated people. \ud \ud INTERVENTIONS: Open treatment with intramuscular midazolam or intramuscular haloperidol plus promethazine. \ud \ud MAIN OUTCOME MEASURES: Patients tranquil or sedated at 20 minutes. Secondary outcomes: patients tranquil or asleep by 40, 60, and 120 minutes; restrained or given extra drugs within 2 hours; severe adverse events; another episode of agitation or aggression; needing extra visits from doctor during first 24 hours; overall antipsychotic load in first 24 hours; and not discharged by two weeks. \ud \u

Year: 2003
OAI identifier: oai:eprints.whiterose.ac.uk:959

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