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Materials and manufacturing technology for the fabrication of bioinspired artifical vascular systems

By Kirsten Borchers, Claas Bierwisch, Sascha Engelhard, Careen Graf, Raimund Jaeger, Petra Kluger, Hartmut Krüger, Wolfdietrich Meyer, Esther Novosel, Oliver Refle, Christian Schuh, Nadine Seiler, Günter E.M. Tovar, Michael Wegener and Tobias Ziegler

Abstract

The key technology for in 3-D vitro engineered tissues is the establishment of vascular scaffolds. Today it is not yet possible to generate vascular structures resembling the typical organisation of mature blood vessels in vivo. In the past, significant progress has been made mainly in the development of tissue-like engineered products that are not dependent on a significant Ievel of vascular support, such as bioartificial cartilage and skin equivalents. The generation of adequate tissue substitutes of most other types of tissues require a functional vascular network for the supply of nutrients and the disposal of metabolites throughout a functional and growing tissue. Therefore, the generation of vascularised artificial tissues defines a challenging topic for future developments

Topics: Inkjet, biomaterial, tissue, Gewebe, Additive Manufacturing (AM), generatives Fertigungsverfahren, digital biofabrication, BioRap®, Biotechnologie, Druckverfahren, Fertigungsprozess, Simulation
Year: 2012
OAI identifier: oai:fraunhofer.de:N-223524
Provided by: Fraunhofer-ePrints
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