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Plasma D-dimer and peritoneal CA-125 levels as predictors of disease status in ovarian carcinoma

By Peter G. Rose, Jill M. Terrien and Stephen P. Baker

Abstract

Although serum CA-125 has improved our ability to monitor tumor response in ovarian carcinoma, approximately 50% of patients with normalization of CA-125 have persistent disease at second look laparotomy. Peritoneal CA-125 and plasma D-Dimer levels were studied to determine if their use could increase the sensitivity for persistent ovarian carcinoma in a population of patients with normal physical examinations, radiologic studies, and serum CA-125 values. Plasma D-Dimer levels were obtained prior to second look laparotomy. The results of peritoneal CA-125 and plasma D-Dimer studies were compared to second look laparotomy results. Differences were evaluated with a one-way analysis of variance. Twenty-seven patients were studied. Peritoneal CA-125 was evaluated in 23 patients and ranged from \u3c 6.3-223 U/ml. There was no statistical difference in peritoneal CA-125 levels between patients whose second look laparotomies were negative, or microscopically or macroscopically positive. D-Dimer was elevated in three patients, all of whom had macroscopically positive second look findings. The sensitivity for positive second look findings was only 27%. Minimally elevated plasma D-Dimer levels were specific but not sensitive for persistent disease and peritoneal CA-125 was not predictive of disease status

Topics: Antigens, Tumor-Associated, Carbohydrate; Carcinoma; Female; Fibrin Fibrinogen Degradation Products; Humans; Laparotomy; Ovarian Neoplasms; Peritoneal Lavage; Predictive Value of Tests; Reoperation; Sensitivity and Specificity; Tumor Markers, Biological, Cancer Biology, Cell and Developmental Biology, Oncology
Publisher: 'Wiley'
Year: 1994
DOI identifier: 10.1002/jso.2930560309/pdf
OAI identifier: oai:escholarship.umassmed.edu:infoservices-1062
Provided by: eScholarship@UMMS
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