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The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation

By J. Peters, M. Stevenson, C. Beverley, J.N.W. Lim and S. Smith

Abstract

Background:\ud \ud This review examines the clinical effectiveness and\ud cost-effectiveness of hand-held inhalers to deliver\ud medication for the routine management of chronic\ud asthma in children aged between 5 and 15 years.\ud Asthma is a common disease of the airways, with a\ud prevalence of treated asthma in 5–15-year-olds of\ud around 12% and an actual prevalence in the community\ud as high as 23%. Treatment for the condition\ud is predominantly by inhalation of medication. There\ud are three main types of inhaler device, pressurised\ud metered dose, breath actuated, and dry powder, with\ud the option of the attachment of a spacer to the first\ud two devices under some prescribed circumstances.\ud Two recent reviews have examined the clinical and\ud cost-effectiveness evidence on inhaler devices, but\ud one was for children aged under 5 years and the\ud comparison in the second was made between pressurised\ud metered dose inhalers and other types only.\ud \ud Objectives:\ud \ud This review examines the clinical effectiveness and\ud cost-effectiveness of manual pressurised metered\ud dose inhalers, breath-actuated metered dose\ud inhalers, and breath-actuated dry powder inhalers,\ud with and without spacers as appropriate, to deliver\ud medication for the routine management of chronic\ud asthma in children aged between 5 and 15 years.\ud \ud Methods:\ud \ud Two previous HTA reviews have compared the\ud effectiveness of inhaler devices, one focusing on\ud asthma in children aged under 5 years and the\ud other on asthma and chronic obstructive airways\ud disease in all age groups. For the current review, a\ud literature search was carried out to identify all\ud evidence relating to the use of inhalers in older\ud children with chronic asthma. A search of in-vitro\ud studies undertaken for one of the previous reviews\ud was also updated.\ud \ud The data sources used were: 15 electronic bibliographic\ud databases; the reference lists of one of the\ud previous HTA reports and other relevant articles;\ud health services research-related internet resources;\ud and all sponsor submissions.\ud \ud Studies were selected according to strict inclusion\ud and exclusion criteria, and relevant information\ud concerning effectiveness and patient compliance\ud and preference was extracted directly on to an\ud extraction/evidence table. Quality assurance\ud was monitored.\ud \ud Economic evaluation was undertaken by reviewing\ud existing cost-effective evidence. Further economic\ud modelling was carried out, and tables constructed\ud to determine device cost-minimisation and\ud incremental quality-adjusted life-year (QALY)\ud thresholds between devices.\ud \ud Results:\ud \ud Number and quality of studies, and\ud direction of evidence: \ud \ud Fourteen randomised controlled studies were\ud identified relating to the clinical effectiveness of\ud inhaler devices for delivering β2-agonists. A further\ud five were on devices delivering corticosteroids and\ud one concerned the delivery of cromoglicate.\ud Overall, there were no differences in clinical\ud efficacy between inhaler devices, but a pressurised\ud metered dose inhaler with a spacer would appear\ud to be more effective than one without. These\ud findings endorse those of a previous HTA review\ud but extend them to other inhaler devices.\ud Seven randomised controlled trials examined the\ud impact on clinical effectiveness of using a nonchlorofluorocarbon\ud (CFC) propellant in place of\ud a CFC propellant in metered dose inhalers, both\ud pressurised and breath activated, although only one\ud study considered the latter type. No differences were\ud found between inhalers containing either propellant.\ud A further 30 studies of varying quality, from 12 randomised\ud controlled trials to non-controlled studies,\ud were identified that concerned the impact of use\ud by, and preference for, inhaler type, and treatment\ud adherence in children. Differences between the\ud studies, and limitations in comparative data between\ud various inhaler device types, make it difficult to draw\ud any firm conclusions from this evidence. \ud \ud Summary of benefits:\ud \ud No obvious benefits for one inhaler device type\ud over another for use in children aged 5–15 years\ud were identified.\ud \ud Costs and cost per quality-adjusted\ud life-year:\ud \ud Two approaches have been taken: cost-minimisation\ud and QALY threshold. In the QALY threshold\ud approach, additional QALYs that each device must\ud produce compared with a cheaper device to achieve\ud an acceptable cost per QALY were calculated. Using\ud the cheapest and most expensive devices for delivering\ud 200 μg of beclometasone per day, assuming no\ud cost offset for any device, and a threshold of £5000,\ud the largest QALY needed was 0.00807. With such\ud a small QALY increase, no intervention can be\ud categorically rejected as not cost-effective.\ud \ud Conclusions:\ud \ud Generalisability of findings:\ud \ud On the available evidence there are no obvious\ud benefits for one inhaler device over another\ud when used by children aged 5–15 years with\ud chronic asthma. However, the evidence, in the\ud majority of cases, was compiled on children\ud with mild to moderate asthma and restricted\ud to a limited number of drugs. Therefore the\ud findings may not be generalisable to those at\ud the more severe end of the spectrum of the\ud disease or to inhaler devices delivering some\ud of the drugs used in the management of asthma.\ud \ud Need for further research:\ud \ud Many of the previous studies are likely to\ud have been underpowered. Further clinical\ud trials with a robust methodology, sufficient\ud power and qualitative components are needed\ud to demonstrate any differences in clinical\ud resource use and patients’ asthma symptoms.\ud Further studies should also include the\ud behavioural aspects of patients towards their\ud medication and its delivery mechanisms.\ud It is acknowledged that sufficient power may\ud prove impractical owing to the large numbers\ud of patients required

Publisher: Core Research
Year: 2002
OAI identifier: oai:eprints.whiterose.ac.uk:1777

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