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A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site

By Antonella Virgilio, Veronica Esposito, Alfonso Mangoni, Luciano Mayol and Aldo Galeone


Investigations of heterochiral oligodeoxynucleotides 50-TD1GD2GD3- 30-30-GL3GL2TL1-50 (L33) and 30-TD1GD2GD3-50-50-GL3GL2TL1-30 (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them

Topics: G-quadruplex, heterochiral oligodeoxynucleotides, inversion of polarity
Publisher: 'Royal Society of Chemistry (RSC)'
Year: 2013
DOI identifier: 10.1039/c3cc44607g
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