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Tissue-specific downregulation of the adiponectin "system": possible implications for fat accumulation tendency in the pig

By A. De Rosa, M.L. Monaco, E. Nigro, O. Scudiero, M. D'Andrea, F. Pilla, G. Oriani and A. Daniele


Adiponectin's beneficial effects are mediated by the AdipoR1 and AdipoR2 receptors (AdipoRs). The pig is a good model to study complex disorders such as obesity. We analyzed the expression of adiponectin, AdipoRs and some key molecules of energy metabolism (AMP-activated protein kinase alpha [AMPK alpha], p38 mitogen-activated protein kinase [p38 MAPK], and PPAR alpha) in 2 pig breeds that displayed an opposite genetic behavior for energy metabolism: Casertana (CE), a fat-type animal, and Large White (LW), a lean-type animal. Muscle, liver, visceral and subcutaneous adipose tissues, and brain tissues were examined. The AdipoRs cDNA sequences were identical in the 2 breeds. AdipoRs mRNA expression, measured in all tissues, was significantly lower only in the 2 adipose tissues of CE pigs (P < 0.05). The muscle expression of AdipoRs, AMPK alpha, p38 MAPK, and PPAR alpha was lower in CE than in LW animals (P < 0.01, P < 0.05, P < 0.01, P < 0.01, respectively). In liver, no molecule differed between breeds. The expression of both AdipoRs in visceral and subcutaneous adipose tissues was lower in CE pigs (P < 0.01). In brain, AdipoR1 and AMPK alpha expression was lower in CE pigs (P < 0.01), whereas AdipoR2 tended to be lower in CE than LW pigs (P = 0.05). In conclusion, our results suggest that tissue-specific downregulation of Adiponectin, AdipoRs, and of the key molecules of energy metabolism may be associated with the tendency of CE pigs to accumulate fat

Topics: Adiponectin, AdipoR1, AdipoR2, Energy metabolism, Pig, Fat accumulation
Publisher: 'Elsevier BV'
Year: 2013
DOI identifier: 10.1016/j.domaniend.2012.11.001
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