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Flavonoid Oligoglycosides from Ophioglossum vulgatum L. Having Wound Healing Properties

By M.Clericuzio, S. Tinello, B. Burlando, E. Ranzato, S. Martinotti, L. Cornara and A. La Rocca

Abstract

Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3)α-rhamnopyranoside]-7-O-α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3)α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI‑MS and ESI-HRMS spectra. Compounds 1–3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20 μM

Publisher: PLANTA MEDICA - GEORG THIEME VERLAG KG, RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Year: 2012
DOI identifier: 10.1055/s-0032-1315149
OAI identifier: oai:iris.unige.it:11567/387426
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