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Factors affecting SPF in vitro measurement and correlation with in vivo results

By Aleksandra Dimitrovska Cvetkovska, Stefano Manfredini, Paola Ziosi, Sonia Molesini, Valeria Dissette, Ilenia Magri, Chiara Scapoli, Alberto Carrieri, Elisa Durini and Silvia Vertuani


The in vitro evaluation of SPF is still a problem due to the lack of repeatability and correlation between the in vitro and in vivo data and many authors are currently working to develop an internationally harmonized method.(1) Very recently, the use of several "adjuvant" ingredients such as boosters, antioxidants, immuno-modulators, solvents and film forming ingredients have further complicated the pattern for product developers, that should frequently run in vivo test. The aim of this study is to understand if a simple and cheap in vitro method could be optimized in order to provide both statistically repeatable and predictive SPF measurement

Topics: SPF in vitro, Claim substantiation, Formulation, Spectroscopy, Sunscreens, Environment
Year: 2016
DOI identifier: 10.1111/ics.12377
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