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Assessing small airway impairment in mild-to-moderate smoking asthmatic patients

By Marco Contoli, Federico Bellini, Luca Morandi, Giacomo Forini, Stefano Bianchi, Giulia Gnesini, Brunilda Marku, Klaus F Rabe and Alberto Papi

Abstract

Asthma is characterised by airway inflammation throughout the bronchial tree, including the small airways. In asthma, small airway alterations are associated with poor clinical outcomes [1]. Cigarette smoke is known to induce peripheral airway abnormalities, asthmatic smokers exhibit a more rapid lung function decline, experience more frequent exacerbations and are more likely to be uncontrolled, even when the disease is managed as recommended [2]. The mechanisms accounting for poor responses to treatment in smoking asthmatic patients are currently unclear, although low accessibility to inhaled medications in the peripheral airways is considered a limiting factor for the efficacy of such treatments [3]

Year: 2016
DOI identifier: 10.1183/13993003.01708-2015
OAI identifier: oai:iris.unife.it:11392/2338369
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