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L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum

By G. Porras, P. De Deurwaerdere, Q. Li, M. Marti, R. Morgenstern, R. Sohr, E. Bezard, M. Morari and W.G. Meissner


L-dopa remains the mainstay treatment for Parkinson’s disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa

Year: 2014
DOI identifier: 10.1038/srep03730
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