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Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.

By Lam KH, Lee KK, Gambari R, Kok SH, Kok TW, Chan AS, Bian ZX, Wong WY, Wong RS, Lau FY, Tong SW, Chan KW, Cheng CH, Chui CH and Tang JC.


The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect

Year: 2014
DOI identifier: 10.1016/j.phymed.2014.02.005
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