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Antiangiogenic VEGF Isoform in Inflammatory Myopathies

By Volpi N., Pecorelli A., Lorenzoni P., Di Lazzaro F., Belmonte G., Agliano' M., Cantarini L., Giannini F., Grasso G. and Valacchi G.


Objective. To investigate expression of vascular endothelial growth factor (VEGF) antiangiogenic isoform A-165b on human muscle in idiopathic in!ammatory myopathies (IIM) and to compare distribution of angiogenic/antiangiogenic VEGFs, as isoforms shi*s are described in other autoimmune disorders. Subjects and Methods. We analyzed VEGF-A and VEGF-A by western 165b and inclusion body myositis) and + control muscle samples. TGF-, a prominent VEGF inductor, was analogously evaluated. blot and immunohistochemistry on skeletal muscle biopsies from " patients aected with IIM (polymyositis, dermatomyositis, with VEGF expression. Results. VEGF-A resulted signi,cantly upregulated in IIM, as well as TGF-. VEGF-A was diusely 165b Intergroup dierences of western blot bands density were statistically examined. Endomysial vascularization, in!ammatory score, and muscle regeneration, as pathological parameters of IIM, were quantitatively determined and their levels were confronted expressed on unaected myo,bers, whereas regenerating/atrophic myo,bres strongly reacted for both VEGF-A isoforms. Most in!ammatory cells and endomysial vessels expressed both isoforms. VEGF-A165b levels were in positive correlation to in!ammatory score, endomysial vascularization, and TGF-. Conclusions. Our ,ndings indicate skeletal muscle expression of antiangio

Year: 2013
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