Location of Repository

Inhibition of bovine β-trypsin, human α-thrombin and porcine pancreatic β-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: Thermodynamic and molecular modeling study

By Menegatti, E., Ferroni, R., Nastruzzi, C., Bortolotti, F., Scalia, S., Amiconi, G., Bolognesi, M., Coletta, M., Onesti, S., Fruttero, R., Ascenzi and P.

Abstract

The inhibitory effect of bis-, tris- and tetra-benzamidine derivatives (DAPP, TAPB and TAPP, respectively) on the catalytic properties of bovine β-trypsin (β-trypsin), human α-thrombin (α-thrombin) and porcine pancreatic β-kallikrein-B (β-kallikrein-B) was investigated (between pH 2.0 and 7.0, I= 0.1 M; T= 37.0 ± 0.5°C), and analyzed in parallel with that of benzamidine, commonly taken as a molecular inhibitor model of serine proteinases

Year: 1991
OAI identifier: oai:iris.unife.it:11392/1682876
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://hdl.handle.net/11392/16... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.