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Inhibition of bovine β-trypsin, human α-thrombin and porcine pancreatic β-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: Thermodynamic and molecular modeling study

By Menegatti, E., Ferroni, R., Nastruzzi, C., Bortolotti, F., Scalia, S., Amiconi, G., Bolognesi, M., Coletta, M., Onesti, S., Fruttero, R., Ascenzi and P.


The inhibitory effect of bis-, tris- and tetra-benzamidine derivatives (DAPP, TAPB and TAPP, respectively) on the catalytic properties of bovine β-trypsin (β-trypsin), human α-thrombin (α-thrombin) and porcine pancreatic β-kallikrein-B (β-kallikrein-B) was investigated (between pH 2.0 and 7.0, I= 0.1 M; T= 37.0 ± 0.5°C), and analyzed in parallel with that of benzamidine, commonly taken as a molecular inhibitor model of serine proteinases

Year: 1991
OAI identifier: oai:iris.unife.it:11392/1682876
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