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Effects of somatostatin on human thyroid folliculi in vitro

By Hanau S, Rossi R, Piva R, Maestri I, Margutti A, Trasforini G, Pansini G, Degli Uberti E and del Senno L

Abstract

Somatostatin (SRIF) inhibits calcitonin and T3-T4 secretion in thyroid. We have investigated the in vitro effect of SRIF on the basal and TSH induced [3H]thy incorporation, thyroglobulin (tgb) RNA and cAMP level in follicular cells, isolated from normal and adenomatous human thyroids. [3H]thy uptake has been evaluated as TCA-precipitable material in 2, 4, 8, 24 h incubated follicles and 24 h incubated adherent cells. Tgb RNA has been quantified with cytoplasmic dot blot hybridization and cAMP level with RIA method. SRIF reduces basal and TSH-induced [3H]thy in both suspension follicles and epithelial adherent cells. However it does not modify tgb RNA nor cAMP levels in incubated follicles. These data suggest a direct antiproliferative effect of SRIF on human thyroid

Topics: Somatostatin, Thyroid
Year: 1990
OAI identifier: oai:iris.unife.it:11392/1682419
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