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High prevalence of BK polyomavirus sequences in HPV-16 positive precancerous cervical lesions.

By M Comar, D Bonifacio, F Zanconatti, M Di Napoli, E Isidoro, F Martini, L Torelli and M Tognon


High and low grade cervical lesions were investigated for Polyomavirus (PYV) and Human Papillomavirus (HPV) sequences. In precancerous cervical lesions, the overall prevalence of PYV sequences was 44% (41/93). Specifically, among PYV-positive samples 83% (34/41) tested positive for BKV sequences, whereas 17% (7/41) were JCV-positive. None of the samples were SV40-positive. BKV DNA in HSIL was confirmed by in situ PCR experiments. BKV sequences were more frequently detected in HSIL, together with HPV-16. The association of BKV with precancerous cervical lesion suggests that this polyomavirus may participate, together with HPV-16, in the cell transformation process. Alternatively, BKV may multiply better in HPV-16 positive cells from precancerous cervical lesions than in HPV-16 negative cells

Topics: papillomavirus, polyomavirus, cervical lesion, viral load
Year: 2011
DOI identifier: 10.1002/jmv.22184
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