Fundamental major efforts have been devoted to the development of\ud positron emission tomography (PET) imaging modality over the last few decades. Recently, a novel surge of interest in single photon emission computed tomography (SPECT) technology has occurred,\ud particularly after the introduction of the hybrid SPECT-CT imaging\ud system. This has led to a flourishing of investigations in new types of detectors and collimators, and to more accurate refinement of reconstruction algorithms. Along with SPECT-CT, new, fast gamma cameras have been developed for dedicated cardiac imaging. The existing gap between PET and SPECT in sensitivity and spatial resolution is progressively decreasing, and this trend is particularly\ud apparent in the field of small animal imaging where the most important advances have been reported in SPECT tomographs. An outline of the basic features of SPECT technology, and of\ud recent developments in SPECT instrumentation for both clinical applications and basic biological research on animal models is described
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