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Genetic expression profiling of parotid neoplasms by cDNA microarrays

By PASTORE A., CARINCI F and PELUCCHI S

Abstract

Differentially expressed genes in various benign and malignant\ud salivary gland tumours were identified by use of cDNA\ud microarrays containing 19,000 human expressed sequence\ud tags. Samples were derived from 5 patients with pleomorphic\ud adenoma, 4 with Warthin’s tumour, one with clear cell\ud carcinoma, and 2 with mucoepidermoid carcinoma.\ud Tumours were classified by using a subset of 486 genes.\ud Benign Warthin’s tumour and pleomorphic adenoma showed\ud very distinctive gene expression patterns. A total of 133\ud genes differentiated the single malignant clear cell carcinoma\ud from non-tumour salivary glands (p < 0.01), whereas\ud only 16 genes separated it from the highly related benign\ud pleomorphic adenoma (p < 0.01). A total of 57 cDNAs were\ud associated with mucoepidermoid carcinoma (p < 0.01). The\ud results show gene expression alterations common to all\ud tumours and unique to each benign and malignant tumour.\ud The numerous Expressed Sequence Tags of unknown function\ud we identified could also become useful as tumour\ud markers and represent a set of novel tumour-associated\ud genes

Topics: parotid tumours, genetic expression, microarrays
Year: 2005
OAI identifier: oai:iris.unife.it:11392/1207492
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