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Separation of white blood cells from erythrocytes on a dielectrophoresis (DEP) based 'Lab-on-a-chip' device.

By BORGATTI M., ALTOMARE L., BARUFFA M., FABBRI E., BREVEGLIERI G., FERIOTTO G., MANARESI N., MEDORO G., ROMANI A., TARTAGNI M., GAMBARI R. and GUERRIERI R.

Abstract

The 'Lab-on-a-chip technology' involves miniaturization of complex analytical procedures and is expected to enable laboratory testing to move from the central laboratory employing complex equipment into non-laboratory settings. We report the application of a printed circuit board (PCB)-based chip, generating dielectrophoretic (DEP)-based cylinder-shaped cages for separation and recovery of white blood cells from erythrocytes. This possibility is of interest to develop low-cost Lab-on-a-chip devices for diagnostic purposes. Accordingly, we demonstrate that white blood cells recovered from this Lab-on-a-chip device are suitable for PCR-based molecular diagnosis procedures employing DNA sequencing or biospecific interaction analysis using surface plasmon resonance and biosensor technology

Year: 2005
OAI identifier: oai:iris.unife.it:11392/1202898
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