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Osteoporosis in beta-thalassemia: Clinical and genetic aspects.

By ORIGA R, FIUMANA E, GAMBERINI MR, ARMARI S, MOTTES M, SANGALLI A, PAGLIETTI E, GALANELLO R and BORGNA C.

Abstract

Osteoporosis and osteopenia are frequent complications of thalassemia major (TM) and intermedia (TI). Osteoporosis was found in 23/25 patients with TI and in 115/239 patients with TM. In TM, no association was found with specific polymorphisms in candidate genes (vitamin D receptor, estrogen receptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosis in female patients with TM was strongly associated with primary amenorrhea (P < .0001), while in male patients with TM, hypogonadism was not significantly related to bone mineral density (BMD) (P = .0001). Low BMD was also associated with cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronic hepatitis (P = .0029), and increased ALT (P = .01)

Topics: thalassemia major, thalassemia intermedia, osteoporosis
Year: 2005
OAI identifier: oai:iris.unife.it:11392/1197365
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