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Cards on t(1;7)(p36;q34) in ANLL; del (13q) in NHL and in B-CLD;



Disease acute non lymphocytic leukemia (ANLL), presenting as a de novo condition or after preceeding myelodysplastic syndrome or exposure to myelotoxic agents \ud Phenotype / cell stem origin M2/M4 by FAB criteria, frequently with trilineage myelodysplasia: positivity for myeloid markers (i.e. CD13, CD33) as well as for CD117, CD34 and TdT; lymphoid-associated markers tested negative in the reported cases \ud Epidemiology the frequency of this anomaly in ANLL is < 1% \ud Prognosis the cells may be susceptible to chemotherapy since all reported cases achieved complete remission, despite the presence of other unfavourable prognostic factors \ud \ud \ud Cytogenetics \ud \ud \ud Note this translocation may be related to a 1p;7q translocation described in myelodysplastic syndrome, whereas it must be distinguished from the T-ALL associated t(1;7)(p32;q34), involving the TCR gene and a more proximal breakpoint on 7q \ud Cytogenetics Morphological the translocation is easy to visualize in G-banded preparations because the dark 7q35 band moves on top of the derivative 1p \ud Probes partial chromosome paints for the 7q31-qter region \ud Additional anomalies associated / additional anomalies may include +8 and the classical t(6;9)(p23;q34) \ud \ud \ud Genes involved and Proteins \ud \ud \ud Note the involved genes are unknown \ud \ud \ud External links \ud \ud \ud Other database t(1;7)(p36;q34) Mitelman database (CGAP - NCBI) \ud Other database t(1;7)(p36;q34) CancerChromosomes (NCBI

Publisher: Genetic University Hospital
Year: 1999
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