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LABELLING OF SMALL MOLECULES\ud WITH THE 99mTc-NITRIDO CORE (cap.15)

By M. PASQUALI, L. UCCELLI, A. BOSCHI and A. DUATTI

Abstract

In the framework of the project focused on the study of labelling methods of small\ud biomolecules with novel 99mTc cores, a number of labelling procedures based on the\ud [99mTc≡N]2+ core have been proposed. It was found that the most useful class of 99mTc\ud complexes for incorporating small bioactive molecules was that of bis substituted\ud complexes with bidentate chelating ligands. This class includes both symmetrically and\ud asymmetrically bis substituted complexes. In symmetrical complexes, two identical\ud bidentate ligands are coordinated to the same Tc≡N group. Conversely, two different\ud bidentate ligands bind to the same metal centre in asymmetrical nitrido complexes. In\ud the paper, a summary of results obtained within the coordinated research project\ud through the application of the chemistry of 99mTc-nitrido complexes is reported

Publisher: IAEA
Year: 2007
OAI identifier: oai:iris.unife.it:11392/518056
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