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Phosphinic platinum complexes with 8-thiotheophylline derivatives: Synthesis, characterization, and antiproliferative activity

By BERGAMINI P., BERTOLASI V., MARVELLI L., CANELLA A., GAVIOLI R., MANTOVANI N., MANAS S. and ROMEROSA A.

Abstract

The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated

Topics: CRYSTAL-STRUCTURES, ANTICANCER DRUGS, Platinum ligands, 1, 3, 5-TRIAZA-7-PHOSPHAADAMANTANE, CYTOTOXICITY, phosphinic platinum complexes, thiotheophylline derivatives
Publisher: American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671
Year: 2007
DOI identifier: 10.1021/ic062133c
OAI identifier: oai:iris.unife.it:11392/470085
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